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KMID : 0361020000430080836
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Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 8 p.836 ~ p.843
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Detection of Human Papillomavirus and Epstein-Barr Virus in Sinonasal Inverted Papillomas and Its Correlation with p53 and Proliferating Cell Nuclear Antigen Expression
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Cho Jin-Hee
Jun Beom-Cho
Suh Byung-Do
Yang Myung-Jae
Yoon He-Ro
Chang Han-Sung
Ro Woo-Young
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Abstract
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Background and Objectives: Sinonasal inverted papillomas are benign but topographically aggressive neoplasms that have a high recurrence rate and seem to be associated with malignancy. The etiology of inverted papilloma remains unknown, but some hypotheses suggest that nasal polyps proliferation and chronic inflammation are due to allergy or various infections lesions. This study was to elucidate the biological the biological characteristics and the role of human papillomavirus (HPV) and Ebstein - Barr virus (EBV) and the expression of p53 protein and proliferating cell nuclear antigen (PCNA) in sinonasal inverted papillomas.
Materials and Methods: We examined 26 specimens from 26 individuals with normal mucosae (n=10) and inverted papillomas (n=16) to determine the occurance of HPV and EBV infection and the expression of p53 protein and PCNA.
Results: Of the 16 Inverted papillomas, HPV DNA was detected in eight cases, HPV 18 was detected in two cases (18%), HPV 16 and HPV 33 were both found in every case (6%), HPV 16 were coinfected in one case (6%), and other types were found in 3 cases. HPV DNA was not detected in the normal nasal mucosae. EBV DNA was detected in 10 cases (62%) out of 16 inverted papillomas and in two cases (20%) of 10 normal nasal mocoase, The altered p53 protein expression was observed in four cases (25%), and positive PCNA staining was detected in four cases (25%) out of 16 inverted papillomas. One positive PCNA staining was detected among 10 normal mucoase. The mean PC10 index was 16.0% in the inverted papillomas group and 4.1% in normal nasal mucosae group.
Conclusion: An inverse correlation may exist between oncogenic HPV infection and p53 alteration in sinonasal inverted papillomas.
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KEYWORD
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Inverted papillomas, p53, Proliferating cell nuclear antigen(PCNA)
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